Last data update: May 06, 2024. (Total: 46732 publications since 2009)
Records 1-5 (of 5 Records) |
Query Trace: Mason KL[original query] |
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Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection
Oliva Chávez AS , Wang X , Marnin L , Archer NK , Hammond HL , Carroll EEM , Shaw DK , Tully BG , Buskirk AD , Ford SL , Butler LR , Shahi P , Morozova K , Clement CC , Lawres L , Neal AJO , Mamoun CB , Mason KL , Hobbs BE , Scoles GA , Barry EM , Sonenshine DE , Pal U , Valenzuela JG , Sztein MB , Pasetti MF , Levin ML , Kotsyfakis M , Jay SM , Huntley JF , Miller LS , Santambrogio L , Pedra JHF . Nat Commun 2021 12 (1) 3696 Extracellular vesicles are thought to facilitate pathogen transmission from arthropods to humans and other animals. Here, we reveal that pathogen spreading from arthropods to the mammalian host is multifaceted. Extracellular vesicles from Ixodes scapularis enable tick feeding and promote infection of the mildly virulent rickettsial agent Anaplasma phagocytophilum through the SNARE proteins Vamp33 and Synaptobrevin 2 and dendritic epidermal T cells. However, extracellular vesicles from the tick Dermacentor andersoni mitigate microbial spreading caused by the lethal pathogen Francisella tularensis. Collectively, we establish that tick extracellular vesicles foster distinct outcomes of bacterial infection and assist in vector feeding by acting on skin immunity. Thus, the biology of arthropods should be taken into consideration when developing strategies to control vector-borne diseases. |
Case Series of Laboratory-Associated Zika Virus Disease, United States, 2016-2019
Hills SL , Morrison A , Stuck S , Sandhu K , Mason KL , Stanek D , Gabel J , Osborne MA , Schroeder BA , Rico E , Drenzek CL , Gallagher GR , Fiddner J , Heberlein-Larson LA , Brown CM , Fischer M . Emerg Infect Dis 2021 27 (5) 1296-1300 Zika virus diagnostic testing and laboratory research increased considerably when Zika virus began spreading through the Americas in 2015, increasing the risk for potential Zika virus exposure of laboratory workers and biomedical researchers. We report 4 cases of laboratory-associated Zika virus disease in the United States during 2016-2019. Of these, 2 were associated with needlestick injuries; for the other 2 cases, the route of transmission was undetermined. In laboratories in which work with Zika virus is performed, good laboratory biosafety practices must be implemented and practiced to reduce the risk for infection among laboratory personnel. |
Evidence of Powassan/deer tick virus in adult black-legged ticks (Ixodes scapularis) recovered from hunter-harvested white-tailed deer (Odocoileus virginianus) in Pennsylvania: A public health perspective
Campagnolo ER , Tewari D , Farone TS , Livengood JL , Mason KL . Zoonoses Public Health 2018 65 (5) 589-594 Studies reporting tick infection rates for Powassan virus (POWV), an emerging zoonotic arthropod-borne pathogen responsible for POWV disease in the Commonwealth of Pennsylvania, are limited. To determine the presence and ascertain a statewide prevalence of POWV, ticks were collected from 9,912 hunter-harvested white-tailed deer (Odocoileus virginianus) heads presented to six regional Pennsylvania Game Commission Chronic Wasting Disease sampling stations in early December of 2013, 2014 and 2015. Of the 2,973 ticks recovered, 1,990 (66.9%) were identified as adult Ixodes scapularis (black-legged tick). The 1,990 I. scapularis ticks were PCR-tested for the presence of POWV. The ticks had a statewide Powassan/deer tick virus infection rate of 0.05%, providing evidence of this pathogen in Pennsylvania's adult I. scapularis ticks and supporting the need for more comprehensive pathogen prevalence assessment strategies, as well as increased public health awareness for this emerging zoonotic arthropod-borne pathogen of public health concern. |
Occupational fatalities resulting from falls in the oil and gas extraction industry, United States, 2005-2014
Mason KL , Retzer KD , Hill R , Lincoln JM . MMWR Morb Mortal Wkly Rep 2017 66 (16) 417-421 During 2003-2013, fatality rates for oil and gas extraction workers decreased for all causes of death except those associated with fall events, which increased 2% annually during 2003-2013 (1). To better understand risk factors for these events, CDC examined fatal fall events in the oil and gas extraction industry during 2005-2014 using data from case investigations conducted by the Occupational Safety and Health Administration (OSHA). Sixty-three fatal falls were identified, accounting for 15% of all fatal events. Among fatal falls, 33 (52%) workers fell from a height of >30 feet (9 meters), and 22 (35%) fell from the derrick board, the elevated work platform located in the derrick (structure used to support machinery on a drilling rig). Fall fatalities occurred most frequently when drilling rigs were being assembled or disassembled at the well site (rigging up or rigging down) (14; 22%) or when workers were removing or inserting drill pipe into the wellbore (14; 22%). Measures that target derrickmen and workers engaged in assembling and disassembling drilling rigs (rigging up and down) could reduce falls in this industry. Companies should annually update their fall protection plans and ensure effective fall prevention programs are in place for workers at highest risk for falls, including providing trainings on proper use, fit, and inspection of personal protective equipment. |
Occupational fatalities during the oil and gas boom - United States, 2003-2013
Mason KL , Retzer KD , Hill R , Lincoln JM . MMWR Morb Mortal Wkly Rep 2015 64 (20) 551-554 During 2003-2013, the U.S. oil and gas extraction industry experienced unprecedented growth, doubling the size of its workforce and increasing the number of drilling rigs by 71%. To describe fatal events among oil and gas workers during this period, CDC analyzed data from the Bureau of Labor Statistics (BLS) Census of Fatal Occupational Injuries (CFOI), a comprehensive database of fatal work injuries. During 2003-2013, the number of work-related fatalities in the oil and gas extraction industry increased 27.6%, with a total of 1,189 deaths; however, the annual occupational fatality rate significantly decreased 36.3% (p<0.05) during this 11-year period. Two-thirds of all worker fatalities were attributed to transportation incidents (479, [40.3%]) and contact with objects/equipment (308 [25.9%]). More than 50% of persons fatally injured were employed by companies that service wells (615 [51.7%]). It is important for employers to consider measures such as land transportation safety policies and engineering controls (e.g., automated technologies) that would address these leading causes of death and reduce workers' exposure to hazards. |
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